New publication from Enric Mocholi (Coffer lab) identifies link between metabolism and gene regulation in Juvenile Idiopathic Arthritis

In this study, the Coffer lab reveals a critical link between cellular metabolism and gene regulation in Juvenile Idiopathic Arthritis (JIA). Enric Mocholi found that activated CD4+ T cells in JIA patients undergo a metabolic shift towards glycolysis, directly influencing histone acetylation and gene expression, fueling inflammation. These findings provide support for targeting metabolism to reshape the epigenome of inflammatory T cells and help modulate immune responses in JIA and beyond. Click here for link to paper.

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Sonia Aristin’s (Coffer lab) PhD research highlighted by Worldwide Cancer Research

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Rodriguez-Colman lab identifies new role for lactate in cancer