Published in NAR: The farnesoid X receptor activates transcription independently of RXR at non-canonical response elements

Here the latest paper of the van Mil group! In this paper we show that RXR acts as a molecular switch, inhibiting FXRα2 activation from ER-2 while enhancing it from canonical IR-1 DNA response elements. The data showcase FXR as the first NR with isoform-specific RXR-independent response elements, highlighting a new layer of regulation and complexity for RXR-heterodimerizing NRs.